Tightness and discomfort in the anterior chest area may be caused by angina pectoris, myocardial infarction, pneumothorax and so on. 1. Angina pectoris: angina pectoris is a heart disease caused by coronary artery atherosclerosis, resulting in narrowing or occlusion of the lumen, myocardial ischemia and hypoxia or necrosis. During the attack, there may be squeezing pain or stuffiness in the chest area, and the pain may radiate to the anterior heart area and the left upper limb. 2. Myocardial infarction: due to acute ischemic necrosis of the heart muscle, resulting in severe chest pain, agitation, near-death sensation, etc. The pain is long and severe, and cannot be relieved by resting or taking nitroglycerin. 3. Pneumothorax: Pneumothorax is caused by air entering into the pleural cavity and compressing lung tissues to affect normal respiratory activity, resulting in chest tightness, shortness of breath, dyspnea and so on. In addition to this, tightness in the chest area may also be caused by other reasons, so please consult a doctor as soon as possible if you feel unwell.