Pemphigus is an autoimmune disease, the existing treatment can only control the disease, it is difficult to completely cure, there is no so-called special-effect drugs. Glucocorticosteroids are the first-line drugs for the treatment of pemphigus, such as prednisone or prednisolone, which are commonly used in the clinic. At the beginning, the appropriate dosage needs to be taken according to the condition, and the dosage is gradually and slowly reduced after one week, and then the drug is taken in small doses for a long period of time for maintenance and prevention of recurrence, which is generally required to be taken for three to five years. Note that long-term use of glucocorticosteroids may be weight gain, poor wound healing, hirsutism and other side effects, you need to strictly follow the instructions of the doctor to use the drug. In order to reduce the dosage of corticosteroids to improve the efficacy, or the effect of glucocorticoids alone is not good, to combine the use of immunosuppressive drugs, such as cyclosporine, cyclophosphamide and so on. For patients with diabetes and glaucoma who cannot take hormonal drugs, immunosuppressants can be used alone. Currently, the biologic agent rituximab is an effective drug for the treatment of pemphigus, and has been used as a first-line drug treatment option in developed countries, while its use in our country is still limited due to its high price. Therefore, glucocorticoids and immunosuppressants are still preferred for the treatment of pemphigus in our country, along with some supportive therapies, Chinese herbal medicine and so on.