The appearance of skin breakouts on the face after using metronidazole gel may be related to the adverse reaction to the medication or to the progression of the disease. The main aspects of treatment include observation, suspension of the drug, and the administration of anti-allergy medication. 1. Metronidazole gel adverse reactions include skin dryness, burning sensation and skin tingling discomfort, etc. When the symptoms continue and signs of aggravation, it is necessary to stop the drug in time and clean the local skin of the drug. 2. For the development of the disease and changes caused by the phenomenon of breakouts, mainly for the cause of the treatment, such as oral doxycycline tablets, topical adapalene gel treatment of acne. In the choice of drug treatment, must strictly follow the doctor’s instructions, adverse reactions to the hospital in a timely manner, under the guidance of the doctor standardized treatment.