Iodophor is one of the most commonly used disinfectants in clinical practice. When iodophor expires, it loses its germicidal effect and also breeds bacteria inside. It is important to check the date of manufacture and shelf life of iodophor when using iodophor, as expired iodophor should not be used anymore. In addition, the opening date of iodophor should be recorded when using iodophor. Generally, the shelf life of iodophor is 7 days after opening the bottle, and it is not recommended to continue using iodophor beyond 7 days. Iodophor can be used for skin disinfection, disinfection of surgical instruments, pre-operative hand brushing, pre-surgical skin disinfection, cleaning of patients after trauma, etc. Iodophor contains no alcohol and is less irritating, so it can also be used for disinfection of mucous membranes, treatment of vaginitis, etc. In addition, when using iodophor for disinfection, you should avoid using red mercury antagonists at the same time to avoid reducing the disinfection effect. Patients who are allergic to iodine should not use iodophor as it contains iodine to avoid allergic reactions, and in severe cases, anaphylactic shock may endanger the patient’s life.