High absolute monocyte values are usually due to physiological or pathological factors, and pathologic factors should be treated aggressively for the primary disease after further investigation. 1. Physiological factors: physiological high absolute monocyte value is common in infants and children, if not accompanied by other uncomfortable symptoms, there is no need for special treatment. Parents should pay attention to good observation, if there are uncomfortable symptoms, such as fever, cough, etc. should seek medical treatment. 2. Pathologic factors (1) Infectious diseases: such as Listeria monocytogenes infection, infective endocarditis, malaria and other acute infectious diseases or acute infections in the recovery period, can be seen in the absolute value of monocytes significantly high. (2) Blood diseases: such as mononuclear cell leukemia, myelodysplastic syndrome, chronic granulocytic leukemia, etc., can appear monocyte absolute value is high. (3) Connective tissue diseases: such as systemic lupus erythematosus, rheumatoid arthritis, etc., the patient’s examination can be seen monocyte absolute value bias. (3) In addition to the above diseases, malignant tumors such as stomach cancer, liver cancer, lung cancer, etc. can also lead to high absolute monocyte value. When the absolute value of monocyte is high, patients should do the next examination and treatment under the guidance of doctors.