What are the common problems with left ventricular diastolic function?

  Normal diastolic filling type In normal young people, myocardial relaxation and left ventricular elastic retraction are rapid and strong, and most of the left ventricular filling is completed in early diastole; as age increases, the rate of myocardial relaxation tends to decrease slowly, leading to a decrease in early diastolic left ventricular filling and an increase in compensatory left atrial contraction in late diastole. Thus, with increasing age, there is a tendency for E to decrease and DT to lengthen, with a gradual increase in A: E peaks are similar around 60 years of age, whereas above 60 years of age usually E/A1 and DT are 160-200 ms. The pseudo-normal filling type represents moderate diastolic abnormalities in patients with evidence of qualitative heart disease (e.g., low EF, left atrial enlargement, left ventricular hypertrophy, etc.).  Restrictive filling type As the disease progresses diastolic function is significantly impaired, significantly increased left atrial pressure leads to shortened early mitral valve opening (IRT) and increased trans-micrometric pressure to increased peak E in early diastole; a small amount of blood filling of the rigid left ventricle (markedly decreased compliance) can lead to a rapid rise in left ventricular diastolic pressure and a shortened DT with rapid equilibration of left ventricular and left atrial pressures; left atrial contraction in late diastole Although left atrial pressure can be increased, a more rapid rise in left ventricular pressure during the same period leads to a decrease in both the speed and duration of the A-peak.