Advanced lung cancer can be treated by targeted drugs, and the clinical decision of whether targeted drugs can be applied is made through genetic testing. There are more classifications of lung cancer, and some lung cancers have better effect by applying targeted therapy, such as lung adenocarcinoma, if there is EGFR mutation, you can choose targeted drugs, such as ametinib, oseltinib, vomitinib, etc. There are fewer targeted drugs that can be chosen for lung squamous carcinoma. Anrotinib for lung adenocarcinoma, lung squamous carcinoma and small cell lung cancer can be tried. There are also immunotherapy therapies, such as PD-1, and patients with mutations in ALK gene can choose targeted drugs such as crizotinib. Patients should consult their specialist for specific indications and methods of drug use and follow medical advice.