Itchy blisters on the soles of the feet may be related to repeated friction, fungal infection, eczema, allergies and other conditions. Depending on the cause of the condition, it should be treated by applying medication (e.g. terbinafine cream, glycerite lotion, etc.), taking oral medication (e.g. itraconazole, loratadine, etc.), and so on. 1. Repeated friction: Blisters on the feet may be caused by factors such as prolonged walking or ill-fitting shoes. Local application of iodine povidone can be used to sterilize the blisters. If the blisters are relatively large, the liquid inside can be extracted out if necessary. 2. Fungal infection: Tinea pedis caused by fungal infection can be externally applied miconazole cream, terbinafine ointment and other medications, and oral terbinafine, itraconazole and other medications if necessary. 3. Eczema: Eczema on the feet can also lead to the gathering of blisters, accompanied by obvious itching sensation, can be coated with glycerine lotion, dexamethasone hydrochloride cream and other medications, together with oral loratadine, cetirizine hydrochloride and other antihistamine medications. 4. Allergy: allergic reactions can also cause itchy blisters on the soles of the feet, oral diclofenac tadine, fexofenadine hydrochloride, vitamin C and other medications, and pay attention to avoid re-exposure to allergenic substances. Caused by blisters on the soles of the feet itchy cause more, it is recommended that the patient to the hospital in a timely manner, follow the doctor’s instructions for treatment, do not self-medication.