What is the cause of intestinal obstruction in advanced ovarian cancer and how to treat it

  The pathogenesis of intestinal obstruction due to ovarian cancer is complex and often occurs due to a combination of factors such as local tumor metastasis, infiltration, and compression. Advanced ovarian cancer often presents with extensive metastasis in the abdominal cavity, local infiltration or adhesions, and eventually develops into intestinal obstruction. Early detection and diagnosis can help to buy valuable time for palliative surgical resection, and clear metastasis and obstruction can be used to select treatment plan more systematically. The diagnosis of ovarian cancer intestinal obstruction is often insidious and the clinical symptoms are complicated, so the diagnosis often needs to be obtained by comprehensive examination results such as imaging, serum tumor marker examination and clinical symptoms. If the abdominal metastasis is more extensive and the obstruction site is not suitable for surgery, conservative medical treatment can be chosen, which is more beneficial to improve the patient’s quality of life.  1. X-ray standing abdominal plain film 4-6 hours after the occurrence of intestinal obstruction, it can show the intestinal cavity is inflated, and the X-ray film can show the intestinal cavity is dilated and the intestinal liquid and gas plane.  2. Abdominal CT examination is more direct and accurate than X-ray plain film, which can show the dilatation of intestinal lumen and intestinal fluid and gas plane, and can evaluate the site and degree of obstruction and the extent of tumor lesion to determine whether the obstruction is low or high obstruction.  3. PET-CT examination As the site of obstruction is mostly located in the small intestine, and the metastatic sites of ovarian cancer include pelvic lymph node metastasis, retroperitoneal lymph node metastasis, recurrence of tumor in and around the intestinal canal and vaginal stump, and the frequency of metastasis in the rest of the body is in the order of intestinal mesentery, peritoneum, liver, peritoneum, bone, abdominal wall and groin, etc. In general, the number of metastases is mostly lymph nodes, and the metastases are mostly confined to the abdominal cavity and pelvis. The metastatic sites and causes of obstruction are not easily determined by conventional examinations such as B-mode ultrasound, CT or barium enema. This examination can clarify the cause and location of obstruction, which is more important for choosing the treatment plan.  Chinese medicine treatment for intestinal obstruction in advanced ovarian cancer At present, Chinese medicine enema and anal drip are the main and most commonly used methods in clinical practice. The rectal enema of Chinese medicine can make the feces in the distal intestine of the obstruction to be discharged and help eliminate the edema of the intestinal tube of the obstructed section. In particular, the Chinese medicine anal drip method increases the route of Chinese medicine administration, and the drugs are absorbed through the rectum, which makes rectal drug administration fast and effective. It overcomes the negative effects of bitter cold medicine on the stomach and intestines, and has local therapeutic effects on lower gastrointestinal tumors and gynecological tumors.  Western medical treatment for intestinal obstruction in advanced ovarian cancer Surgery for cancerous obstruction can completely remove the cause of obstruction or change the intestinal pathway, which is the fundamental method of treatment, but there are therapeutic difficulties in surgery for cancerous obstruction. It is suitable for patients with limited tumor, single-site obstruction, and may benefit from further chemotherapy and anti-tumor therapy, as well as patients for whom non-surgical treatment is ineffective. Patients with extensive abdominal metastases, massive ascites with recurrence after drainage, poor general condition, advanced age, and severe cardiac and pulmonary disorders should not be treated surgically.