People with genetic disorders or their parents should always do genetic counseling before deciding to have the next generation. It is an absolute mistake to come back after pregnancy and ask if the child is at risk, when there is usually no time for prenatal diagnosis and we cannot help you. Prenatal diagnosis is required for hereditary diseases, and stopping the inheritance of the disease within the family is not only the responsibility of the nation, but also a responsibility that should be assumed by the family members. Before having prenatal diagnosis both spouses should discuss fully and be prepared psychologically. The steps to perform prenatal diagnosis are: 1. Specific diagnosis of genetic diseases and mutated genes, and clarification of the mode of inheritance. Generally the examination from the previous onset of the patient can be determined. 2, clarify which diseases can be genetic examination, general gene mutation patients with sex-linked inheritance and dominant mode of inheritance, need to do prenatal genetic examination, recessive inheritance is generally not passed to the children’s generation, but to the generation of grandchildren, grandchildren need genetic examination. Mitochondrial disease caused by mitochondrial gene mutations, generally cannot be determined by genetic examination whether the next generation has mitochondrial disease. 3. An agreement needs to be signed with the hospital to be able to perform prenatal genetic diagnosis of the examination. We will work with the neurologist and obstetrician-gynecologist of the hospital where we will be seen and the technician who will perform the genetic test to determine the timing of the pregnancy and the time of the prenatal test. Genetic testing is usually done at 12 weeks of pregnancy for chorionic villus, at 16 weeks for amniotic fluid, and at 20 weeks for cord blood.4 If both spouses are genetically predisposed to the disease, IVF can be performed by combining someone else’s sperm or egg with their own egg or sperm to form an embryo, which can then be implanted in the uterus. This method is simpler and can produce a healthy child from a purely biological point of view, but sociologically it always makes one of the spouses feel that the child is not entirely their own.5. The parents do not have disease-causing genes and it is determined that the child has a de novo mutation of their own, without the need for prenatal genetic testing.