There are various manifestations of calcium deficiency, such as osteoporosis, poor development and twitching of the hands and feet, but it does not usually lead to symptoms of muscle soreness, especially in the case of sore calves if there is no obvious cause, other systemic diseases such as vascular system and neurological system cannot be ruled out and prompt medical attention is needed to perform relevant venous ultrasound and electromyography of both lower limbs to clarify the causative cause.