The causes of toe pain when sleeping at night are soft tissue inflammation of the toes, gout, nail groin infection and other conditions. 1. Soft tissue inflammation: toes exertion or cold will cause non-infectious inflammation, causing toe pain, often feel pain when sleeping quietly. 2. Gout: Patients suffering from gout have elevated uric acid due to impaired purine metabolism. Urate crystals are deposited in the joints, causing toe pain. 3. Infertitis: Inflammation of the tissues around the toenail due to infection by pathogenic microorganisms, causing toe pain. There may be other reasons for toe pain at night, so it is recommended to consult a doctor in time to find out the cause of the disease and treat the cause of the disease.