Age-related pemphigus is pemphigus foliaceus, an autoimmune subepidermal pemphigoid that is prevalent in the elderly. The probable cause is damage to the basement membrane bands caused by antigen-antibody binding resulting in blistering. The cause of pemphigus foliaceus is not fully understood, and it is currently thought to be a possible cause of blistering due to damage to the basement membrane bands as a result of antigen-antibody binding. However, it has been found that pemphigus foliaceus occurs in elderly patients with different types of dementia, Parkinson’s disease, cerebrovascular disorders and epilepsy. In particular, patients with multiple sclerosis were at highest risk. Neurologic disorders appear to increase the risk of pemphigus foliaceus. Lesions of pemphigus foliaceus occur on the chest and abdomen and on the proximal extremities, hands, and feet. Typical lesions are tense blisters or blisters with thick, hemispherical walls on top of normal-appearing skin or erythema; the blisters do not break easily, and after rupture, the vesicles are often covered with scabs or crusts, which may heal spontaneously. The disease is mainly treated by oral glucocorticosteroids such as prednisone and immunosuppressants such as mertiomacrophenol ester. Mild cases can be treated with strong glucocorticoid ointment such as Halometasone applied over a large area. It is recommended that patients need to go to the dermatology department of the hospital in a timely manner to improve the examination and make a clear diagnosis, and use medication under the guidance of the doctor.