The most common cause of breast swelling and discomfort when menopause is approaching is still a clinical manifestation due to abnormal levels of hormone secretion. At such a time, there is a significant differential change in the level of hormone secretion, and the breasts appear distended and painful as the target organ of hormones, similar to normal mastopexy. The localized swelling and discomfort of the patient’s breast also becomes different from before due to the irregularity of menstruation, and the patient’s emotions are easily affected at this time, which also causes the swelling and discomfort of the breast. Another condition is that the breast is prone to lesions during this period. In addition to normal breast occupancy, the incidence of breast cancer increases compared to other ages, and when a sudden malignant tumor of the breast invades other tissues, it can also cause breast swelling and discomfort. Another condition may be inflammation of the breast, which occurs at a higher rate if the patient has an invaginated nipple. For this particular period, ultrasound examination should be performed as early as possible for this symptom of mastitis to make a clear diagnosis.