The wound after kidney transplant usually hurts for about 1-2 days and the pain will not last long. If the pain is prolonged after kidney transplantation it may be caused by rejection or infection. It needs to be treated with medication according to the specific situation. 1. Rejection reaction: after kidney transplantation rejection reaction, there may be swelling and pain in the kidney area, accompanied by increased blood creatinine, oliguria, hematuria and other symptoms and signs, this situation requires the use of immunosuppressants such as tacrolimus to reduce rejection reaction. 2. Infection: A common complication after kidney transplantation is infection, which may cause pain near the wound. As a large amount of immunosuppressant is needed to fight rejection after kidney transplantation, it may make the body’s immunity decrease and easily cause infection. So you need to pay extra attention to wound care after kidney transplantation to avoid wound infection. If long-term pain occurs after kidney transplantation, you should consult a doctor in time to clarify the cause of the disease and then carry out targeted treatment under the guidance of the doctor.