There is no immediate solution to stop coughing at night in adults. There are many reasons why adults cough at night, such as cough variant asthma, bronchitis, gastroesophageal reflux disease, etc., which can be treated with medication. 1. Cough variant asthma: because of its airway hyperresponsiveness, most attacks at night, manifested as paroxysmal cough, easy to wake up coughing. In this case, you can use inhalation drugs, such as budesonide formoterol powder inhalation, etc. to relieve the symptoms, and you can also take leukotriene receptor antagonists such as montelukast and other drugs. 2. Bronchitis: Acute bronchitis can lead to worsening of cough at night due to vagus nerve excitation at night. If it is dry cough, central cough suppressant can be used, such as dextromethorphan, etc. If it is cough with phlegm that is not easy to cough up, aminoglutethimide, bromhexine, etc. can be used to resolve phlegm. 3. Gastroesophageal Reflux Disease (GERD): GERD is characterized by reflux of gastric contents when lying down, which is manifested as irritating cough, and can be relieved and treated with drugs that inhibit gastric acid such as omeprazole and gastric stimulants such as mosapride. Adults who cough at night can also be caused by cardiac insufficiency, if the symptoms are not relieved or aggravated, it is necessary to go to the regular hospital for examination, under the guidance of the doctor to use drugs.