Betamethasone can treat gout and should be used in accordance with medical advice. Gout is a common clinical disease, but the etiology and pathogenesis are still unclear. Gout patients in the acute stage, can follow the doctor’s advice with glucocorticoid treatment, and betamethasone belongs to the glucocorticoid class of drugs, suitable for glucocorticoid-sensitive acute and chronic diseases, so betamethasone can treat gout. Some patients may experience adverse reactions such as water-electrolyte disorders, muscle weakness, and abdominal distension after applying betamethasone treatment. If the patient is allergic to betamethasone or other glucocorticoid drugs, the drug is contraindicated; if the patient has a systemic fungal infection, the drug is also prohibited, so as not to aggravate the condition. It is recommended that patients go to the rheumatology and immunology departments of regular hospitals and follow the doctor’s instructions to use medication, do not self-medication.