Lamotrigine and sodium valproate are both commonly used antiepileptic drugs and both have side effects, the magnitude of which varies from person to person and cannot be directly compared. Sodium valproate is the broadest-spectrum antiepileptic drug and is the first-line medication for disorienting seizures, generalized tonic-clonic seizures in adults, and other types of epilepsy. Common adverse effects are tremor, nausea, vomiting, weight gain, hair loss, and menstrual disorders. Lamotrigine is one of the newer antiepileptic drugs that are more effective in partial seizures and can also be used in generalized epilepsy as well as in the treatment of absence seizures. Common adverse effects of this drug include diplopia, dizziness, ataxia, and rash. Lamotrigine and sodium valproate are both commonly used antiepileptic drugs, and each person has a different body type and a different magnitude of side effects from taking the drugs, so their side effects cannot be directly compared. Therefore, no matter which drug is taken, adverse reactions may occur after taking the drug, so under the guidance of a specialist physician, combined with their own disease conditions and individual factors, choose the appropriate drug treatment, do not blindly self-medication.