Both retinoic acid cream and adapalene cream belong to the retinoic acid group of drugs, which are irritating to the skin, so it is not recommended to combine them. Retinoic acid cream is mainly used for the treatment of common acne and keratosis pilaris, which can regulate the abnormally keratinized epithelial cells and affect the production of melanocytes, thus improving the symptoms of epithelial dyskeratosis and reducing skin pigmentation. Adapalene ointment is mainly used for the treatment of acne, especially for acne characterized by pimples and inflammatory papules. Both retinoic acid cream and adapalene gel are prone to irritation during application, leading to symptoms such as dryness, redness, tingling or prickling of the skin, so it is not recommended to use both on the same lesion. It is contraindicated for those who are allergic to retinoic acid cream or adapalene gel. Contraindicated for pregnant and lactating women. Contraindicated in acute or subacute dermatitis. Patients are advised to use the medication under the guidance of a doctor and in strict compliance with the doctor’s instructions, and not to use the medication blindly or change the dosage of the medication without authorization.