Headaches in patients with encephalitis may be caused by the severity of the disease, causing increased intracranial pressure, and can be treated with cranial pressure-lowering therapy. Commonly used medications include mannitol, glycerol fructose and also tachyphylaxis and sodium beta-heptaphylloside. In addition, it may also be caused by encephalitis itself, which is an infectious disease of the central nervous system, usually caused by a viral infection. Patients mainly present with headache, nausea, and vomiting. The main focus is to actively treat the primary cause, including antiviral therapy as well as neuroprotective therapy, and the drugs used for antiviral therapy, generally applying acyclovir and ganciclovir. If the patient has severe symptoms, early treatment with dexamethasone or prednisone can also be applied, which may promote the absorption of inflammation and help the patient recover from the disease. If the patient has severe headache, some symptomatic pain medications can also be applied, such as intramuscular injection of pindecoxin and oral administration of ibuprofen.