There is no clinical best treatment for babies with high fever of 38.5 degrees Celsius. Parents should give their babies physical cooling or antipyretic drugs in time and take them to the doctor for medication. 1. If the baby does not show crying, irritability and other discomforts, you can carry out physical cooling for the baby. Use warm water to wipe the baby’s head, armpits and other locations throughout the body to help metabolize body heat. Note that due to the baby’s delicate skin, can not use alcohol wipe. 2. If the baby has a high fever of 38.5 degrees Celsius and is not comfortable, you need to give your baby antipyretic drugs, such as ibuprofen, acetaminophen, etc. Commonly administered orally, suppositories can also be used appropriately for uncooperative babies. 3. If the baby is younger, under 3 months old, or if the fever is high for more than 48 hours, or if the parents do not know how to deal with it, they should take the baby to the doctor immediately to prevent the adverse effects of febrile convulsions (convulsions and seizures due to high fever) or persistent high fever on the brain function. When the baby has a high fever of 38.5 degrees Celsius, parents should keep calm and give the baby medication as prescribed by the doctor. Since high fever can lead to loss of body fluids, parents should ensure that their babies drink enough water to prevent water-electrolyte disorders.