Colonoscopy shows colorectal congestion and edema without ulceration, which can be treated with mesalazine suppositories. Enteroscopy shows congestion and edema of the mucosa of the colorectal tract, and acute and chronic colorectal inflammation is considered. Inflammatory bowel appears edematous and affects the function of the gastrointestinal digestive system. Mesalazine has a significant inhibitory effect on the inflammation of the intestinal wall. Mesalazine inhibits the formation of leukotrienes, the inflammatory mediators that cause inflammation, as well as the synthesis of prostaglandins. The medication is usually administered by inserting a suppository into the anus after defecation. The drug is contraindicated in people who are allergic to salicylic acid drugs, in people with hepatic and renal insufficiency, in pregnant and lactating women. If colorectal mucosal congestion and edema occurs, do not use the drug on your own, you need to consult a doctor as soon as possible to avoid delaying the condition.