A large flat bumps consider the following diseases: 1, flat warts: this disease is a sexually transmitted disease syphilis stage II rash. You can find flat, slightly moist surface papules or plaques in the perianal area, vulva, in the clinical treatment can be intramuscular injection of benzathine penicillin injection, static point cefuroxime sodium injection, clindamycin phosphate injection, in order to kill the syphilis spiral bacteria. The treatment period should avoid sexual contact with others to avoid the occurrence of cross-infection. 2, urticaria: in the circumference of the body can be seen when the flat bumps, accompanied by a certain itching sensation. The clinical treatment can be oral Avastin capsules, combined with compound glycopyrrolate tablets, and external application of glyburide lotion, during the treatment period need to avoid alcohol.