Whether the fontanel closes early or late has any effect on the child needs to be alerted to the possibility of diseases, such as cerebral atrophy, microcephaly, cytomegalovirus infection, and so on. Due to individual differences, the closure of fontanel may be early or late. The normal time for the fontanel to close completely should be around 1.5 to 2 years of age, if it closes too early, it may lead to craniosynostosis and microcephaly, which will affect the child’s neurological function and is not conducive to the development of intellect. If it is not caused by disease, but simply closes early, not combined with the deformity of the head, can be observed and followed up, usually no adverse effects. Late closure, such as after 3 years of age is still not closed, need to be highly alert to the delayed closure of fontanel, may be hypothyroidism, chondrodysplasia and other disease factors lead to, we recommend that timely pediatrician to consult a doctor, and comply with the doctor’s instructions to be targeted treatment.