In addition to pain, patients with stones may experience nausea and vomiting. This is especially true for stones in the kidney or upper ureter because the sensory nerves that innervate the upper ureter or kidney have a communication branch with the nerves of the gastrointestinal tract through the retroperitoneal ganglion. When there is irritation of the upper ureter, it can lead to an abnormal response of the gastrointestinal tract, with spasms or abnormal sensation, and the patient will experience nausea and vomiting, even if some patients present mainly with nausea and vomiting, with pain appearing later than nausea and vomiting. During the treatment process, stones are treated, extracorporeal shock wave lithotripsy is performed, and anti-infection pain relief is administered. When the stone is discharged, the irritation disappears and the symptoms of nausea and vomiting can be relieved naturally. When the stone is discharged into the ureter and enters the lower part of the ureter, the symptoms of nausea and vomiting can also disappear. It is difficult to cause nausea and vomiting symptoms because the ganglion of the lower ureter has fewer traffic branches with the gastrointestinal tract.