Ulcerative colitis diarrhea and blood in stool can be treated by symptomatic treatment, drug treatment and surgery. 1. Symptomatic treatment: ulcerative colitis diarrhea, blood in stool is more serious, need to replenish fluids to correct the water electrolyte disorders, severe anemia can be given blood transfusion, parenteral supplemental nutrition therapy. 2. Pharmacotherapy: Liuzosulfapyridine, prednisone, azathioprine, infliximab monoclonal antibody and other drugs can be given to treat the disease. 3. Surgery: Surgery should be considered only when the internal medicine treatment is ineffective or when serious complications occur, such as total colectomy, ileal pouch anastomosis and other surgical treatments can be considered. Ulcerative colitis diarrhea, blood in the stool, it is recommended to consult a doctor in a timely manner, under the guidance of targeted treatment.