A 2-hour postprandial blood glucose of 22 mmol/L is usually serious. Normal 2-hour postprandial blood glucose should be strictly controlled at less than 7.8 mmol/L. The 2-hour postprandial blood glucose refers to the blood glucose value measured 2 hours from the time the patient takes the first bite of the meal to the time of blood collection. If the long-term 2-hour postprandial blood glucose reaches 22mmol/L, it may lead to a sharp increase in the incidence of cardiovascular disease, diabetic microproteinuria and diabetic retinopathy, and can be accompanied by itchy skin, cognitive disorders, and in severe cases, ketoacidosis can occur, which can be life-threatening, and therefore more serious. In addition, if the 2-hour postprandial blood glucose reaches 22mmol/L, you should immediately go to the hospital for hospital-related examinations to clarify the specifics of the disease and actively cooperate with the doctor’s treatment.