Generalized itching in pregnant women may be caused by allergy, eczema in pregnancy, intrahepatic cholestasis in pregnancy and other reasons. 1. Allergy: when pregnant women use seafood or contact allergens, allergic reactions will occur, manifested as generalized itching, accompanied by rash or urticaria, according to the medical history, clinical manifestations, etc. can be clearly diagnosed. 2. Eczema in pregnancy: it will also cause generalized itching, manifested as recurrent skin eczema, especially in hot and humid seasons, usually has no effect on the fetus, combined with medical history and clinical manifestations can help diagnosis. 3. Intrahepatic cholestasis in pregnancy: it occurs in late pregnancy, itching starts at the end of the limbs and may spread to the whole body without rash. It may be accompanied by skin scratches, and some pregnant women may also have mild jaundice, which can be diagnosed by combining clinical manifestations with serum bile acids and liver function measurements. In clinical practice, when pregnant women with generalized itching need to go to the hospital in time to identify the cause and actively deal with it.