Itchy and painful corners of the eyes, eyes always feel unable to open is usually caused by conjunctivitis, keratitis, dry eye and other eye diseases. 1. Conjunctivitis: It can be caused by bacterial, viral and chlamydial infections, as well as allergies, autoimmune diseases, etc. Patients usually manifest foreign body sensation in the eyes, burning sensation, increased secretion, itchy eyes, photophobia, tearing and other symptoms. The corners of the eyes may feel itchy and painful, and the eyes always feel unable to open. 2. Keratitis: Keratitis is usually caused by bacterial, viral, fungal and parasitic infections or autoimmune diseases, which can lead to inflammation of the corneal tissues, thus showing typical symptoms of irritation such as itchy eyes, eye pain, photophobia, tearing, and eyelid spasm. Patients may feel that the corners of their eyes are itchy and painful, and their eyes always feel that they can’t open. 3. Dry eye: usually caused by insufficient tear secretion, excessive tear evaporation and other factors, which can lead to inadequate wetting of the eye, inducing damage to the ocular surface tissues, the patient may manifest for the dryness of the eyes, foreign body sensation, blurred vision, vision fluctuations, easy to visual fatigue, etc., but also can be manifested as the corner of the eyes itchy and painful, the eyes always feel can’t be opened. Eye corner itching pain, eyes always feel open, can also be caused by other reasons, patients should consult a doctor in time to clarify the cause of the disease, follow the doctor’s instructions for treatment.