Peeling and itching toes are considered to be related to tinea pedis, eczema, exfoliative keratolysis and other etiologies. After clarifying the cause of the disease, the symptoms can be relieved by antifungal drugs, glucocorticoids and vitamins. 1. Tinea pedis: commonly known as foot fungus, is caused by dermatophytes infecting the skin of the feet. Treatment is mainly based on antifungal drug therapy, topical drugs, including ketoconazole ointment, bifonazole cream, clotrimazole ointment and so on. Oral medications include itraconazole capsules, terbinafine hydrochloride tablets and so on. 2. Eczema: the specific cause of the disease is not clear, and is currently believed to be related to a variety of internal and external factors. Treatment is based on glucocorticoid drugs, such as methylprednisolone tablets, halometasone cream, etc., which can control the condition. 3. Exfoliative Keratolysis: Exfoliative Keratolysis occurs in the foot, resulting in localized peeling and itching. Repeated peeling or cracking can be given salicylic acid ointment. Vitamin C and vitamin B are effective in the treatment of this disease. For severe symptoms, tretinoin acetate can be given in small doses, which can relieve the inflammatory response. Frequent peeling, localized with obvious pain or combined with infection, it is recommended to consult the dermatology department of the hospital in time, and standardize the treatment under the guidance of the doctor.