Taking progesterone and smoking may cause respiratory disease, endocrine disruption, causing the reaction of the drug, but also affect the effect of the drug, abdominal pain, diarrhea, nausea, vomiting and a series of symptoms. Progesterone is a progesterone drug, in taking progesterone is to avoid smoking and drinking, because smoking is not only prone to respiratory disease, but also prone to endocrine disruption, affecting the effect of the drug. It may also cause a reaction to the drug, sometimes with abdominal pain, diarrhea, nausea, vomiting and a series of symptoms. In addition, the specific use of progesterone should be under the guidance of a doctor. During the period of taking the medication, the diet should be light and mild, avoiding all kinds of cold, spicy, greasy, oily, fat, seafood, hot pot, barbecue and other food intake, avoiding smoking and drinking.