Which is more effective for a toothache, roxithromycin or amoxicillin, needs to be judged on a case-by-case basis; each person is different and therefore the appropriate medication is not the same. But not all toothaches require the use of antibacterial drugs. Roxithromycin and amoxicillin are both antibiotics that can inhibit bacterial infections and avoid aggravation of symptoms, so you can use these two drugs under the guidance of a doctor, and there is no difference between good and bad. It is recommended to actively seek medical examination after the appearance of toothache, part of the toothache using antibiotic drugs may not achieve significant therapeutic effect, but also need to carry out other treatments, such as the appearance of endodontitis, periapical inflammation and other diseases may need to carry out root canal treatment, purely rely on the medication can not be relieved.