The difference between Isosorbide Mononitrate Tablets and Nicorandil is reflected in the drug composition, action and side effects. The drug composition of isosorbide mononitrate tablets is nitrate, which is a drug belonging to the dinitrate class. The mechanism of action is to dilate peripheral arteries and veins, reduce the volume of return blood, reduce the burden on the heart, reduce ventricular pressure, increase coronary blood flow, and improve the symptoms of myocardial hypoxia and ischemia. Its side effects are manifested by low blood pressure and reflex increase in heart rate. Nicorandil is a potassium channel opener and the drug components have nitric acid-like effects. Nicorandil inhibits vascular smooth muscle contraction, which in turn dilates the coronary arteries and improves ischemia of the heart muscle. Nicorandil has no effect on blood pressure and heart rate, this drug is relatively mild. The use of Isosorbide Mononitrate Tablets and Nicorandil needs to be under the supervision of a doctor.