Apical botulism needs standardized treatment and can be cured. 1. caries, trauma or other physical and chemical factors stimulate the pulp infection, failure to carry out timely and effective treatment, with the prolongation of time chronic periapical periodontitis occurs, chronic inflammation recurrence, apical area of the tissue of inflammatory fibrosis, usually known as apical granuloma. 2. The occurrence of chronic apical granuloma is not self-healing, the need for standardized endodontic treatment, remove the infected lesions, and under local anesthesia, the apical part of the inflammation of the fibrotic tissues for scraping, after standardized treatment, the apical granuloma can generally be restored. The emergence of apical granuloma, the need for timely medical treatment, under the guidance of the doctor for standardized treatment, to avoid delays in the condition, resulting in adverse consequences.