The harms of drinking large amounts of coffee on a regular basis to women may include poor sleep, gastrointestinal discomfort, induced osteoporosis and other harms. 1. Poor sleep: the caffeine in coffee has a certain refreshing effect, women who consume coffee for a long time may have a faster heartbeat, accompanied by panic and other manifestations, which may lead to affect the sleep. 3. Gastrointestinal discomfort: caffeine can produce some stimulation of the gastric mucosa, long-term intake of large quantities of coffee may lead to diarrhea, bloating and other gastrointestinal discomfort. 4. Induced osteoporosis: women who consume excessive amounts of coffee for a long period of time may cause bone loss, thus inducing osteoporosis. To summarize, it is recommended not to consume too much strong coffee for a long period of time, and only drink it in moderation when needed, and seek medical advice in case of discomfort.