The nature of multiple thyroid nodules is not always the same. The nature of thyroid nodules can vary and should be determined based on the shape, size, cysticity, benign or malignant nature of the nodules, and different types of nodules can coexist in the same patient. Thyroid nodules are usually detected on ultrasound of the neck. Multiple nodules are more common and most often benign, while single nodules have a higher risk of malignancy. In addition, signs such as well-defined borders, regular shape of the nodule, and homogeneous internal echogenicity also indicate that the nodule is more likely to be benign. In addition to benign and malignant, thyroid nodules can also be differentiated according to the shape, size and cysticity of the nodules, and nodules of different natures can coexist in the same patient. For patients with multiple thyroid nodules, they should have regular follow-up examinations at local hospitals to observe changes in the nodules.