Patients with advanced liver metastasis of rectal cancer usually choose surgical treatment, chemotherapy, targeted therapy, immunotherapy and other methods according to the different conditions of each patient. 1. Surgical treatment is generally suitable for single small liver metastases, and rectal cancer patients have no complications such as obstruction or perforation, usually radical resection of rectal cancer lesions can be taken, combined with resection of liver metastases at the same time. 2. Chemotherapy is generally suitable for patients with liver metastasis of rectal cancer who are in advanced stage with good physical condition, and commonly used drugs include oxaliplatin, irinotecan, fluorouracil, etc., which are often used in combination of two or three drugs. 3. Targeted drugs are bevacizumab, cetuximab, furaquintinib, regorafenib, etc. Among them, bevacizumab and cetuximab are often used in combination with chemotherapeutic drugs. 4. Immunomedicine is generally used for patients with microsatellite unstable rectal cancer liver metastasis, and commonly used medicines include pembrolizumab, nabulizumab, karelizumab, etc. Once diagnosed with rectal cancer liver metastasis, patients should be treated with immunomedicine. Once diagnosed with liver metastasis of rectal cancer, it is recommended to consult hospitals as soon as possible for standardized treatment by professional doctors.