HCG refers to human chorionic gonadotropic hormone in blood, MOM value is also called median multiple, taking median multiple can well reduce the error caused by different instruments and other factors. HCGMOM value is an important indicator of Down’s syndrome screening, high HCGMOM value indicates that the fetus has the risk of genetic metabolic diseases. The HCGMOM value may be higher than that of singleton pregnancies of the same gestational age, and the HCG value may be inaccurate when the gestational age count is inaccurate; 2. pathological reasons: Down’s syndrome screening is a common method for prenatal screening of chromosomal genetic disorders, and a high HCGMOM value may be related to trisomy 21 and trisomy 18. The high HCGMOM value may be related to trisomy 21 and trisomy 18, indicating that the fetus is at risk of malformation. When a high HCGMOM value occurs during pregnancy testing, do not be overly anxious first. It is recommended to follow the doctor’s advice for further examination, such as amniocentesis or non-invasive DNA testing to detect whether the fetus carries the disease-causing gene, and then proceed to the next step according to the specific test results and doctor’s recommendation.