There are more symptoms of headache when taking antihypertensive drugs for the first time, and many of them are caused by oral calcium channel antagonists, such as nifedipine and amlodipine. These drugs have a certain vasodilating effect, which leads to changes in cerebral blood flow and headache. If the headache is tolerable, the patient can be temporarily observed without excessive stress, and appropriate attention can be paid to rest and not to excessive changes in body position. If the headache is more severe, the patient should measure the blood pressure, if the blood pressure is in a stable state, below the normal value, in this case, oral ibuprofen can be taken to relieve the symptoms of headache, and many cases can choose to rest or apply painkillers such as ibuprofen to relieve the symptoms. If the blood pressure is particularly high, there must be attention to bring it down to the normal range in time.