Pancreatic cancer in advanced stage may cause rib pain. In the early stage of pancreatic cancer, since the cancer cells have not metastasized and spread, there are often no specific symptoms, and generally there is no rib pain, but after entering the advanced stage, the cancer cells metastasize with the lymphatic system and blood to the pleura and ribs, and then cause damage to the surrounding tissues and nerves, and then the patient may have rib pain. Rib pain caused by pancreatic cancer can be treated with non-opioid, weak opioid, strong opioid such as ibuprofen, tramadol, morphine and so on according to the degree of pain, which can improve the quality of life of the patients; at the same time, systemic and localized radiotherapy, chemotherapy and surgical treatments can also be carried out to control the development of the disease and prolong the survival cycle. It is recommended that patients seek timely medical treatment and actively cooperate with doctors to avoid delays.