For the phenomenon of vitiligo around the anus, you can cooperate with the doctor to choose to apply tacrolimus ointment topical treatment, but also other treatments, such as 308 excimer laser. 1. tacrolimus ointment belongs to the calcium-modulated phosphatase inhibitor, can be used for the treatment of eczema, vitiligo and other inflammatory skin diseases, especially for the face, the anus and other mucous membranes thin and tender can not tolerate the side effects of hormones in the parts, can play a certain therapeutic role, but need to pay attention to the tacrolimus itself has a certain degree of irritation, the first time you need to a small amount of medication, to establish tolerance. 2. In addition to medication, 308 excimer laser can also treat vitiligo, vitiligo is characterized by selective black cell destruction, and autoimmune reaction, 308 excimer laser can promote vitiligo lesions within the activated T-cells apoptosis, so as to inhibit immune response and achieve the purpose of the restoration of color. It is recommended that after the diagnosis of vitiligo, the patient should cooperate with the doctor as soon as possible to carry out standardized treatment, to avoid further development of the disease, affecting the patient’s prognosis.