Highly differentiated hepatocellular hepatocellular carcinoma should be based on its stage to develop the best treatment plan, such as surgical treatment, targeted therapy, minimally invasive therapy, etc. Hepatocellular hepatocellular carcinoma is the most common primary malignant liver tumor, and its histological differentiation varies greatly; highly differentiated hepatocellular carcinomas can resemble normal liver tissues very much, whereas poorly differentiated hepatocellular carcinomas have greater tissue heterogeneity. Highly differentiated hepatocellular hepatocellular carcinoma is morphologically similar to normal hepatocytes; therefore, it often needs to be differentiated from normal hepatocytes or benign liver lesions. Commonly used treatments for highly differentiated hepatocellular carcinoma include surgery, targeted therapy, minimally invasive therapy and so on. 1. Surgery: radical resection is currently one of the most effective treatments for hyperfractionated hepatocellular carcinoma. Although current surgical techniques can remove some large hepatocellular carcinomas, whether the functional reserve of the residual liver can maintain the patient’s life is the key to the success or failure of the surgery, and surgical modalities include partial hepatectomy, hemihepatectomy and so on. 2. Targeted therapy: Sorafenib and lenvatinib are molecularly targeted drugs that are more frequently used in the treatment of advanced liver cancer. Highly differentiated hepatocellular carcinoma is also invasive and can also metastasize, so it can be used as appropriate. 3. Minimally invasive treatment: including vascular intervention, radiofrequency ablation, microwave ablation and so on. 4. Chemotherapy: drugs include cisplatin, fluorouracil and so on. If high differentiated hepatocellular carcinoma is diagnosed, it is recommended to carry out standardized treatment as early as possible in order to reduce the adverse effects of the disease. The above drugs should be used under the guidance of physicians and avoid self-medication.