Negative elastin fiber staining for lung cancer usually means that the lung cancer cells have not yet invaded the dirty layer of pleura, but still need to be treated under the guidance of professional doctors. Lung adenocarcinoma elastic fiber staining is a routine test after lung adenocarcinoma surgery, which is usually an immunohistochemistry result of postoperative pathological examination of lung adenocarcinoma, and its positivity usually means that the tumor cells have already invaded the dirty pleura, but we cannot rely on the results of elastic fiber staining to judge whether the dirty pleura has been invaded or not, but should combine with the results of pathological examination of the patient to judge the specific situation. If there is invasion of the visceral pleura, postoperative adjuvant chemotherapy, local radiotherapy, targeted therapy and immunotherapy should be used in combination with lymph node metastasis and distant metastasis to prolong the patient’s life cycle.