At the turn of winter and spring, the climate changes a lot and the body cannot adapt to it, so it will have colds and diarrhea. Patients with chronic nephritis and chronic renal insufficiency are more likely to have these conditions because of their weak constitution. The cold and diarrhea often become triggering factors that aggravate chronic nephritis and chronic renal insufficiency. Chinese medicine has characteristics in the treatment of chronic kidney disease, and there are certain methods in the prevention and treatment of colds and diarrhea. 1, cold: ① when the body is slightly unwell, feel like a cold, you can ginger boiled water, while hot to take, after serving pay attention to keep warm, to a slight sweat for the degree; or hot water to take plate blue root. It can play a role in the early prevention and control of colds. ②If there is already a bad cold, fever, headache, nasal congestion, and it is a wind-cold cold, you can take Zheng Chai Hu, adults can take 2 packets/time. At the same time, you can drink ginger water. ③If sore throat, fever, nasal congestion and fever are wind-heat colds, you can take Yin Qiao tablets or Gua Frost Antipyretic, or ask a Chinese medicine practitioner to prescribe a decoction of herbal medicine to clear wind and heat for oral consumption. For patients with cough and fever, bronchitis and pneumonia may appear. They should be promptly seen by a nephrologist and, if necessary, treated by a doctor with reasonable antibiotics. 2. Diarrhea: ①If the discharge is like water, abdominal pain, no fever, no pus and blood stool, you can take Pure Yang Zheng Qi Pills or Huo Xiang Zheng Qi Pills (or water or capsules) orally. ②If the discharge is like pus and blood stool, the internal urgency is heavy, fever and vicious cold, you can first take Huang Lian Su orally, and promptly go to the hospital.