Brucellosis, or brucellosis, develops as a result of infection with the bacterium Brucella abortus. Whether infusion is still needed after 21 days of infusion should be decided according to the antimicrobial treatment of the infected person, and the course of treatment should be prolonged appropriately if necessary to prevent relapse and chronicity. Pathogenic treatment of brucellosis usually applies doxycycline, rifampicin, cotrimoxazole tablets, etc. Whether infusion is still needed after 21 days of infusion should be decided according to the treatment. If the organic damage and neurological lesions caused by brucellosis are still serious, the infusion time can be extended appropriately; if the symptoms are significantly relieved, the infusion can be appropriately stopped as prescribed by the doctor, but the oral drug treatment still needs to be continued. Brucellosis generally has a good prognosis, but the prerequisite is to give standardized treatment in accordance with the principles of early, combined, regular, appropriate amount, and full treatment. For acute infections, the usual course of treatment should be up to 6 weeks; for chronic infections or the presence of comorbidities, the total course of treatment can be up to 3 months and above, and several courses of treatment need to be repeated if necessary. Patients with brucellosis should have a correct outlook on the disease, have patience and confidence in the treatment, follow the doctor’s instructions for medication, and also undergo regular follow-ups, and consult the doctor if they feel unwell.