Chronic pain is a problem that is often overlooked. 80% of depressed patients present to the hospital with various chronic pain symptoms, often seeking medical rather than psychiatric care, with multiple tests that do not reveal a cause to explain the pain, and because internists do not have specialized psychiatric knowledge, they are unable to identify the real problem in such patients. In fact, the vast majority of these chronic somatic pains arise due to depression and are well treated with antidepressants. However, patients often consult psychiatric specialists only when repeated visits to other departments are ineffective, which delays the condition and increases the patient’s suffering. Therefore, early identification and treatment of such somatic chronic pain can largely reduce patients’ suffering and improve the chances of cure. After patients receive regular and systematic antidepressant treatment, the above-mentioned somatic pain and emotional symptoms will be relieved and they will return to the community as soon as possible.