The main role of probiotics is to regulate the intestinal flora, jaundice drink probiotics generally have no effect. But for neonatal jaundice, probiotics have a certain role. Jaundice is mainly due to abnormal bilirubin metabolism, when bilirubin is produced in excess (e.g. hemolytic anemia, etc., so that the destruction of red blood cells increases), the liver cell’s metabolism of bilirubin decreases (e.g. cirrhosis, etc., so that the normal function of the liver cell is destroyed) or bilirubin excretion obstacles (gallstones, etc., so that bile is unable to excrete the disease), jaundice may be caused. Probiotics refer to bacteria that are beneficial to human body, such as Bifidobacterium bifidum, Bacillus subtilis, Lactobacillus, etc. The main function is to regulate the intestinal flora and maintain the stability of the microenvironment of the gastrointestinal tract, which is mainly used for the treatment of diseases caused by intestinal flora disorders. Therefore, probiotics have no therapeutic effect on jaundice. However, for breast milk jaundice in infants and young children, probiotics such as Bacillus subtilis can reduce the intestinal absorption of bilirubin, promote intestinal peristalsis, and facilitate the discharge of bilirubin, which to a certain extent can also alleviate jaundice. Patients with jaundice are advised to seek timely medical attention and receive treatment actively. Drugs must be taken strictly in accordance with the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition.