Most patients with high uric acid are due to a decrease in primary uric acid excretion. Most commonly, decreased uric acid excretion by the renal tubules leads to an increase in primary uric acid. Excessive uric acid production is also a cause of hyperuricemia. Patients who consume a high purine diet, such as animal offal, seafood and bananas, will experience increased uric acid production, which can also lead to hyperuricemia. Hyperuricemia is also seen in kidney disease such as glomerulopathy, which leads to decreased filtration of uric acid. In addition, excessive uric acid production is also seen in neoplastic diseases such as myeloma and lymphoproliferative diseases, and during chemotherapy for leukemia and lymphoma, which can lead to accelerated nucleic acid metabolism due to massive cell destruction, which in turn can lead to secondary hyperuricemia.”