Cold hands and feet with upper heat and lower cold (heat in the upper part and cold in the lower part) can be treated with heat and cold tonics such as umeboshi pills. Upper heat and lower cold is one of the manifestations of mixed heat and cold (both cold and heat symptoms appear in the same patient). On the one hand, cold is felt in the upper part of the body and symptoms such as coldness (fear of cold), nausea and vomiting, and white fur on the tongue are seen; on the other hand, heat is knotted in the lower part of the body and symptoms such as abdominal distension, constipation, and reddish urination are seen. Treatment usually requires clearing the upper part of the body and warming the lower part of the body, and it is recommended to take Wu Mei Pills to regulate the heat and cold. Wu Mei Pill is composed of Wu Mei meat, pepper, fine Xin, Huang Lian, etc. It has the effect of clearing the upper and warming the lower part of the body and can be used for ascaris lumbricoides, prolonged dysentery, and syncopal headache (headache caused by disease evils encroaching on the syncopal meridian), with symptoms such as coldness in the hands and feet, restlessness and vomiting, and headache at the top of the head, etc. The adverse effects are not known. Adverse effects of Wu Mei Pills are not clear, the general public can take, but pregnant women are prohibited. If there is a need for medication, it should be used under the guidance of a doctor to identify the evidence, and should not be used blindly on its own, so as not to cause adverse consequences.