Platelet specific volume is the percentage of platelet volume in the peripheral blood to the total blood volume. An increased platelet volume is commonly seen in conditions with an increased platelet count, such as myeloproliferative disorders, commonly known as true erythrocytosis, primary thrombocytosis, early stages of myelofibrosis, and chronic granulomatous leukemia. Also, reactive platelet elevation can occur in certain conditions, commonly acute inflammation, major surgery, severe bleeding, and certain tumors, which can also result in increased platelet counts and can also lead to increased platelet specific volume. Decreased platelet specific volume is commonly seen in the case of reduced platelet count. The most common diseases include immune thrombocytopenic purpura, thrombotic thrombocytopenic purpura, drug-related thrombocytopenia, and thrombocytopenia in the case of aplastic anemia. Also, after chemotherapy in patients with malignant neoplasms, a decrease in platelet ratio can occur due to a decrease in the number of platelets.